After running decent fuels in my car for way over 6mths now ive always wondered if there really is that much difference?

Ive always been using Tesco99 with the occasional trip to a Shell garage for some Optimax (now V-Power)
Last week I got caught out near on empty and had to stick some normal unleaded in..........Can I tell the difference?

My word yes the car feels like it's running like a bag of nails to be honest! Switching back the other way you can clearly notice the difference!